ATP synthase Antibodies

Target Information

Complex V, also called F1F0ATPase or ATP synthase, is responsible for ATP production in oxidative phosphorylation and can work in reverse as a proton pumping ATPase. The enzyme was thought to be localized exclusively to mitochondria. However, it has recently been identified on the plasma membrane of several cell types including hepatocytes where it functions as the HDL receptor, on endothelial cells where it may act as the angiostatin receptor, and on the surface of cancer cells. The enzyme in mammals is composed of 17 subunits, five of which make up the easily detached F1. The remainder subunits are components of two stalk domains and the proton pumping F0 part of the machinery. Two of the subunits of the F0 part are encoded on mitochondrial DNA while the other subunits are nuclear encoded. Mutations in the mitochondrial-encoded subunits of ATP synthase (Complex V) cause OXPHOS disease.

Synonyms

0610008F14Rik; 0610009D10Rik; 1110019H14Rik; 1500000I11Rik; 1700094F02Rik; 1810041M08Rik; 2410043G19Rik; 2610008D24Rik; 4933437C06Rik; 6.8 kDa mitochondrial proteolipid; 6.8 kDa mitochondrial proteolipid protein; A6L; AA960090; AI876556; alpha subunit ATP synthase isoform precursor (EC 3.6.1.34); ATP synthase alpha chain, mitochondrial; ATP synthase alpha subunit; ATP synthase alpha subunit precursor; ATP synthase B chain, mitochondrial; ATP synthase c subunit; ATP synthase D chain, mitochondrial; ATP synthase e chain, mitochondrial; ATP synthase epsilon chain, mitochondrial; ATP synthase f chain, mitochondrial; ATP synthase F(0) complex subunit B1, mitochondrial; ATP synthase F(0) complex subunit C1, mitochondrial; ATP synthase F(0) complex subunit C2, mitochondrial; ATP synthase F(0) complex subunit C3, mitochondrial; ATP synthase F0 subunit 6; ATP synthase F0 subunit 8; ATP synthase F1 subunit alpha; ATP synthase F1 subunit beta; ATP synthase F1 subunit delta; ATP synthase F1 subunit epsilon; ATP synthase F1 subunit gamma; ATP synthase g chain, mitochondrial; ATP synthase gamma chain, mitochondrial; ATP synthase gamma-subunit gene encoding a mitochondrial protein; ATP synthase inhibitor protein; ATP synthase lipid-binding protein; ATP synthase lipid-binding protein, mitochondrial; ATP synthase membrane subunit 6.8PL; ATP synthase membrane subunit c locus 1; ATP synthase membrane subunit c locus 2; ATP synthase membrane subunit c locus 3; ATP synthase membrane subunit e; ATP synthase membrane subunit f; ATP synthase membrane subunit g; ATP synthase peripheral stalk subunit d; ATP synthase peripheral stalk subunit F6; ATP synthase peripheral stalk subunit OSCP; ATP synthase peripheral stalk-membrane subunit b; ATP synthase protein 8; ATP synthase proteolipid P1; ATP synthase proteolipid P2; ATP synthase proteolipid P3; ATP synthase proton-transporting mitochondrial F(0) complex subunit B1; ATP synthase proton-transporting mitochondrial F(0) complex subunit C1; ATP synthase proton-transporting mitochondrial F(0) complex subunit C2; ATP synthase proton-transporting mitochondrial F(0) complex subunit C3; ATP synthase subunit 9; ATP synthase subunit a; ATP synthase subunit alpha, mitochondrial; ATP synthase subunit ATP5MPL, mitochondrial; ATP synthase subunit b; ATP synthase subunit b, mitochondrial; ATP synthase subunit beta, mitochondrial; ATP synthase subunit d, mitochondrial; ATP synthase subunit delta, mitochondrial; ATP synthase subunit e, mitochondrial; ATP synthase subunit e, mitochondrial, N-terminally processed; ATP synthase subunit epsilon, mitochondrial; ATP synthase subunit f, mitochondrial; ATP synthase subunit g, mitochondrial; ATP synthase subunit gamma, mitochondrial; ATP synthase subunit O, mitochondrial; ATP synthase, H+ transporting mitochondrial F1 complex, alpha subunit; ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 2; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9); ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9); ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9); ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d isoform a; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit E; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6